Krebs, Hans Adolf, Sir

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Mildred Cohn was a biochemist and biophysicist. She received her Ph.D. from Columbia University in 1938 and was a research associate in biochemistry at several universities (George Washington University, 1937-1938; Cornell University, 1938-1946; Washington University, 1946-1960; Harvard Medical School, 1950-1951). In 1960 she moved to the University of Pennsylvania, where she was professor of biophysics and physical chemistry, 1961-1978; Benjamin Rush Professor of Physiological Chemistry, 1978-1982; and professor emeritus of physiological chemistry, 1982-2009.

From the guide to the Mildred Cohn papers, 1947-1980, 1947-1980, (American Philosophical Society)

This extensive archive comprises the personal and scientific working papers of the distinguished biochemist Sir Hans Adolf Krebs (1900-1981), Nobel prizewinner in 1953 (with Franz Lipmann) for Physiology and Medicine in recognition of his elucidation of the metabolic process known as the tricarboxylic acid cycle or citric acid cycle. The collection was assembled from several sources associated with Krebs at various dates between July 1982 and June 1986, and consists not only of material relating to his work in biochemistry and medicine but also biographical and autobiographical papers, writings on the history and philosophy of science, sociobiology and criminality, speeches, conference papers, publications, lectures and broadcasts, correspondence and photographs.

Krebs was born in 1900 to a Jewish family in Hildesheim, Germany, where his father was a doctor. After studying medicine successively at the universities of Gttingen, Freiburg and Munich he served, amongst other positions, as Research Assistant to the pioneering biologist Otto Warburg in the Kaiser Wilhelm Institut fr Biologie, Berlin-Dahlem, from 1926 to 1930, and then at the Municipal Hospital of Altona. In 1931 he moved to the Department of Medicine at the University of Freiburg, gaining international recognition for the discovery of the ornithine cycle when his work was published the following year. But the accession to power of the Nazis early in 1933 led quickly to his dismissal and flight to England, where it had proved possible to offer him a relatively minor post in Cambridge. In 1935 he moved to Sheffield, having obtained a lectureship, initially in pharmacology but three years later transferring to biochemistry, and where his second major discovery, of the citric or tricarboxylic acid cycle was made and published in 1937 (remarkably, the journal Nature turned down this paper when it was offered to them and it was published in Enzymologia ). During the war years he worked on nationally important research relating to diet and nutrition, particularly the role of vitamins, as a member of Sheffield's Sorby Institute. In 1945 the Medical Research Council set up a Unit for Research in Cell Metabolism at Sheffield, as head of which Krebs was given Professorial status, and which remained in being under his leadership until his retirement in 1967, though transferring with Krebs and most of his research team to Oxford in 1954. The Sheffield period saw the award to Krebs of two major honours: Fellowship of the Royal Society in 1947, and the Nobel Prize for Physiology and Medicine (jointly with Franz Lipmann) in 1953. Many other honours and awards followed during the rest of his career.

In 1954 he was offered and accepted the Whitley Chair of Biochemistry at Oxford University, and his MRC work continued in the Metabolic Research Laboratory in the Radcliffe Infirmary. In 1958 he received a knighthood. Although officially retiring in 1967 he continued to work, funded by the MRC and other grants, until his death in 1981 at the age of 80.

In accordance with the terms of Professor Krebs's will his papers were offered to the University of Sheffield. The considerable task of sorting and cataloguing them was undertaken by Jeannine Alton and Peter Harper of the Contemporary Scientific Archives Centre, and their three-volume catalogue of the Papers was published in 1986.

There is as yet no complete full-scale biography. Krebs published a memoir Reminiscences and reflections, in collaboration with Anne Martin, Clarendon Press 1981, and there is a two-volume biography up to the year 1937 by Frederic Lawrence Holmes Hans Krebs, Oxford University Press, 1991-93.

From the guide to the Hans Adolf Krebs Papers, [ca. 1915]-1982, (University of Sheffield Library)

Archival Resources
Role Title Holding Repository
referencedIn Francis John Worsley Roughton papers, Circa 1920-1960 American Philosophical Society
referencedIn Sir Frederick Gowland Hopkins: Papers, 1845-1947 Cambridge University Library, Department of Manuscripts and University Archives
creatorOf Hans Adolf Krebs Papers, [ca. 1915]-1982 University of Sheffield Library
creatorOf Mildred Cohn papers, 1947-1980, 1947-1980 American Philosophical Society
referencedIn Hans Adolf Krebs Papers, [ca. 1915]-1982 University of Sheffield Library
referencedIn Scientists Collection, 1563-1973 American Philosophical Society
referencedIn Papers and correspondence of Alexander George Ogston, 1911-1996, 1933-1986 Department of Western Manuscripts, Bodleian Library, University of Oxford
referencedIn Reginald Hems Notebooks, 1946-1984 University of Sheffield Library
referencedIn Leonard Victor Eggleston Notebooks, 1941-1974 University of Sheffield Library
referencedIn Miscellaneous Manuscripts Collection, 1668-1983, Bulk, 1750-1850, 1668-1983 American Philosophical Society
Role Title Holding Repository
Relation Name
associatedWith Agassiz, Louis, 1807-1873 person
associatedWith Banks, Joseph, Sir, 1743-1820 person
associatedWith Bothner-By, Aksel A., 1921- person
associatedWith Boyer, Paul D. person
associatedWith Carnegie-Mellon University. NMR Facility for Biomedical Studies. corporateBody
associatedWith Cohn, Mildred, 1913- person
associatedWith Cooper, Thomas, 1759-1839 person
associatedWith Cori, C. F., (Carl Ferdinand), 1896-1984 person
associatedWith Cori, Gerti Theresa Radniz, 1896-1957 person
associatedWith Coues, Elliott, 1842-1899 person
associatedWith Cuvier, Georges, Baron, 1769-1832 person
associatedWith Darlington, William, 1782-1863 person
associatedWith Du Vigneaud, Vincent, 1901-1978 person
associatedWith Edison, Thomas A., (Thomas Alva), 1847-1931 person
associatedWith Einstein, Albert, 1879-1955 person
associatedWith Everett, Edward, 1794-1865 person
associatedWith Fitch, John person
associatedWith Genth, F. A., (Frederick Augustus), 1820-1893 person
associatedWith Gray, Asa, 1810-1888 person
associatedWith Greeley, Horace, 1811-1872 person
associatedWith Grunberg-Manago, Marianne, 1921- person
associatedWith Harding, Warren G. person
associatedWith Hems, Reginald person
associatedWith Institute for Cancer Research (Philadelphia, Pa.). corporateBody
associatedWith Leonard Victor Eggleston person
associatedWith Medical Research Council 1910 - 1997 corporateBody
associatedWith Newcomb, Simon person
associatedWith Newton, Isaac, Sir, 1642-1727 person
associatedWith Noda, Lafayette, 1916- person
associatedWith Oxford University Department of Biochemistry corporateBody
associatedWith Poinsett, Joel Roberts, 1779-1851 person
associatedWith Rittenhouse, David, 1732-1796 person
associatedWith Rose, Irwin A., 1926- person
associatedWith Roughton, Francis John Worsley, 1899-1972 person
associatedWith Rush, Benjamin, 1746-1813 person
associatedWith Schoolcraft, Henry Rowe, 1793-1864 person
associatedWith Seybert, Adam, 1773-1825 person
associatedWith Sir Frederick Gowland Hopkins person
associatedWith Sir Hans Adolf Krebs person
associatedWith Sparks, Jared, 1789-1866 person
associatedWith Stevens, Henry person
associatedWith Sully, Thomas, 1783-1872 person
associatedWith Thomson, Charles, 1729-1824 person
associatedWith University of Pennsylvania. Faculty. corporateBody
associatedWith University of Sheffield Department of Biochemistry corporateBody
associatedWith University of Sheffield Department of Pharmacology corporateBody
associatedWith University of Sheffield Sorby Research Institute corporateBody
associatedWith Urey, Harold Clayton, 1893-1981 person
associatedWith Waterton, Charles, 1782-1865 person
associatedWith Wayne, Anthony person
Place Name Admin Code Country
Subject
Biochemists Germany
Biochemistry
Occupation
Women scientists
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Birth 1900-08-25

Death 1981-11-22

Britons

English

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